Novel drug delivery system using acoustic control of intratumoral drug distribution

Novel drug delivery system using acoustic control of intratumoral drug distribution

Background/introduction An approach of drug delivery to hypovascular tumor tissues is proposed. For such tumor tissues, it is difficult to deliver anti-tumor agents at enough concentration and duration by either systemic or local administration. If we could manipulate the distribution of locally injected drugs by ultrasound, an efficient drug therapy would be possible. We have found that locall...

Novel transdermal drug delivery systems

Background and aim: Eczema is a common inflammatory skin disease. Although history and physical examination are important in diagnosis of allergen, because of extent of environmental allergens, those are not simply recognized. The objective of this study was to determine allergens in patients with contact or atopic dermatitis referred to Razi hospital.Materials and Meth...

Phytosome: Drug Delivery System for Polyphenolic Phytoconstituents

      Several plant extracts and phytoconstituents, despite having excellent bioactivity in vitro, demonstrate less or no in vivo actions due to their poor lipid solubility or improper molecular size or destruction in gut. Drug delivery system for polyphenolic phytoconstituents (phytosomes) was prepared by complexing polyphenolic phytoconstituents with phospholipid mainly phosphatidylcholine wh...

Microemulsions: A potential novel drug delivery system

Niosomes: A Novel Drug Delivery System

Paul Ehrlich, in 1909, initiated the development for targeted delivery when he envisaged a drug delivery mechanism that would target directly to diseased cell. Drug targeting can be defined as the ability to direct a therapeutic agent specifically to desired site of action with little or no interaction with non target tissue 1 . In noisome, the vesicles forming amphiphile is a non-ionic surfact...