Novel controlled and targeted releasing hydrogen sulfide system exerts combinational cerebral and myocardial protection after cardiac arrest

Abstract Background Cardiac arrest (CA) is a leading cause of death worldwide. Even after successful cardiopulmonary resuscitation (CPR), the majorities survivals are companied with permanent myocardial and cerebral injury. Hydrogen sulfide (H 2 S) has been recognized as novel gasotransmitter exerting multiple organ protection; however, lacks ideal H S donors which can controlled release to targeted organs such heart brain limits its application. Results This work utilized mesoporous iron oxide nanoparticle (MION) carriers diallyl trisulfide (DATS), polyethylene glycol (PEG) lactoferrin (LF) modified MIONs acquire prolonged circulation time brain-targeting effects, releasing system was constructed (DATS@MION-PEG-LF), exhibited excellent biocompatibility, controlled-releasing pattern, targeting features, ability be non-invasive traced by magnetic resonance imaging. DATS@MION-PEG-LF presented potent protective effects against cardiac ischemic injury CA in both vitro hypoxia/reoxygenation models vivo CA/CPR models, mainly involves anti-apoptosis, anti-inflammatory anti-oxidant mechanisms. Accordingly, functions were obviously improved CA/CPR, potentially survival. Conclusions The present provides unique platform for based on MIONs, offers new method combinational protection from injury, bringing considerable benefits patients.