Notifications and Health Consequences of Unauthorized Pharmaceuticals in Food Supplements

Health concerns associated with the consumption of food supplements rise in parallel popularity and market availability these products. In pursuit data related to unauthorized presence pharmaceuticals supplements, Rapid Alert System for Food Feed (RASFF) database was searched 2011–2022 period. The most “popular” adulteration were phosphodiesterase-5 inhibitors (235 records); anorexics laxatives (76), including sibutramine its active metabolite N-didesmethyl sibutramine, phenolphthalein 2,4-dinitrophenol; stimulants, among which 1,3-dimethylamine (97), synephrine (53) numerous; nootropic drugs (24); anabolics prohormones (16); cannabinoid cannabidiol (14) (pending authorization as a novel ingredient). Over 65% notifications interest classified serious risks, over 80% alert or border rejection notifications, mainly generated result official control on market. alarming number RASFF should be considered public health issue, demanding clear targeted recommendation action legislature authorities. A harmonized nutrivigilance system tool detect scrutinize adverse effects along measures improve their safety, quality, testing.