Notch signaling and Notch signaling modifiers
نویسندگان
چکیده
منابع مشابه
Notch signaling.
The Notch/Lin-12/Glp-1 receptor family mediates the specification of numerous cell fates during development in Drosophila and Caenorhabditis elegans. Studies on the expression, mutant phenotypes, and developmental consequences of unregulated receptor activation have implicated these proteins in a general mechanism of local cell signaling, which includes interactions between equivalent cells and...
متن کاملNotch signaling.
The Notch pathway regulates cell proliferation, cell fate, differentiation, and cell death in all metazoans. Notch itself is a cell-surface receptor that transduces short-range signals by interacting with transmembrane ligands such as Delta (termed Delta-like in humans) and Serrate (termed Jagged in humans) on neighboring cells (Fig. 1). Some soluble ligands have also been identified in Caenorh...
متن کاملNotch signaling and CADASIL.
Notch signaling plays an essential role in vascular development and human vascular diseases. In adults, mutations of the Notch3 gene cause a hereditary vascular degenerative disease known as cerebral autosomal dominant arteriopathy with subcortical infarct and leukoencephalopathy (CADASIL). CADASIL is characterized by recurrent strokes and cognitive impairment. Over the past decade, the number ...
متن کاملNotch Signaling Components
Non-small-cell lung cancer (NSCLC) is a lethal and aggressive malignancy. Currently, the identities of prognostic and predictive makers of NSCLC have not been fully established. Dysregulated Notch signaling has been implicated in many human malignancies, including NSCLC. However, the prognostic value of measuring Notch signaling and the utility of developing Notch-targeted therapies in NSCLC re...
متن کاملNotch signaling genes
Notch intercellular signaling is essential to cell fate decisions during differentiation, especially in stem cells and progenitor cells. It is also involved in controlling proliferation, survival, and homeostasis in many cell types. Notch signaling genes are targets for pathogenic mutations, including those associated with cancer. In the skeletal muscle lineage, Notch signaling is implicated in...
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ژورنال
عنوان ژورنال: The International Journal of Biochemistry & Cell Biology
سال: 2011
ISSN: 1357-2725
DOI: 10.1016/j.biocel.2011.08.005