منابع مشابه
Is Recombinant Human TSH a Trigger for Graves' Orbitopathy?
The pathogenesis of Graves' orbitopathy (GO) remains unknown. The hypothesis of a causal relationship between autoimmunity against the TSH receptor (TSHR) and GO is supported by clinical studies. Radioiodine treatment is associated with worsening or new onset of GO, possibly via antigen shedding or by inducing hypothyroidism. The coexistence of thyroid cancer with Graves' disease (GD) and GO is...
متن کاملAcademic nepotism – all that glitters is not gold
Dear Editor With increasing emphasis on publications forfaculty recruitment, career advancementand obtaining research grants, the issues relatedto author kinship and academic nepotism havegrown significantly and these probably reflectthe inflationary growth rather than the optimalgrowth warranted due to increasing researchcomplexity. Allesina S (1) measured the fullmagnitude of nepotism in the ...
متن کاملNot All Orbitopathy Is Graves’: Discussion of Cases and Review of Literature
INTRODUCTION Graves' orbitopathy is the extra thyroidal manifestation of Graves' disease and the most common cause of exophthalmos. It is also known as thyroid-associated orbitopathy (TAO) as it occasionally occurs in euthyroid or hypothyroid patients with chronic thyroiditis. 5% of patients with Graves' orbitopathy can be euthyroid or hypothyroid as they have low titers of anti-thyrotropin-rec...
متن کاملDifferences in TSH receptor binding and thyroid-stimulating properties between TSH and Graves' IgG. Slowly-acting TSH receptor antibody moieties in Graves' sera affect assay data.
We analyzed TSH receptor (TSHR) effects, both binding and thyroid-stimulation, of TSH and Graves' IgG. A new TRAb assay system utilizes rhTSHR coated tubes and is comprised of two step incubation, the first incubation with patient serum followed by a second incubation with 125I-bTSH. We called TRAb measured by this method as hTRAb. 125I-bTSH binding capacity of the tube was found close to satur...
متن کاملKIR Gene Content Does Not Contribute to Susceptibility to Graves’ Disease
Background: Killer cell immunoglobulin-like receptors (KIR) are expressed on NK cells and a subset of T cells. The variable KIR receptors along with their ligands, HLA class I, influence risk for autoimmune and malignant diseases. Objective: To investigate the KIR gene profiles in relation to susceptibility to Graves’ disease in patients with ophthalmopathy. Methods: KIR genes profiles were ana...
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ژورنال
عنوان ژورنال: An International Journal of Otorhinolaryngology Clinics
سال: 2014
ISSN: 0975-444X,0975-6957
DOI: 10.5005/jp-journals-10003-1147