Normal tissue complication probability modeling for cochlea constraints to avoid causing tinnitus after head-and-neck intensity-modulated radiation therapy
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چکیده
منابع مشابه
Normal tissue complication probability modeling for cochlea constraints to avoid causing tinnitus after head-and-neck intensity-modulated radiation therapy
BACKGROUND Radiation-induced tinnitus is a side effect of radiotherapy in the inner ear for cancers of the head and neck. Effective dose constraints for protecting the cochlea are under-reported. The aim of this study is to determine the cochlea dose limitation to avoid causing tinnitus after head-and-neck cancer (HNC) intensity-modulated radiation therapy (IMRT). METHODS In total 211 patient...
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Radiotherapy planning studies have confirmed dosimetric advantages of intensity-modulated radiation therapy over conventional and conformal radiation therapy. Utilization of intensity-modulated radiation therapy is ideal in head and neck cancer patients. Critical structures can be spared due to sharp dose gradients and limited organ motion with correct immobilization. Initial clinical results h...
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Introduction: The ultimate goal of radiation treatment planning is to yield a high tumor control probability (TCP) with a low normal tissue complication probability (NTCP). Historically dose volume histogram (DVH) with only volumetric dose distribution was utilized as a popular tool for plan evaluation hence present study aimed to compare the radiobiological effectiveness of the cobalt-60 (Co...
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Introduction: Radiation therapy is the main treatment method for head and neck cancers, which comprise 3–5% of all cancers. A major side effect of this treatment is complication of the parotid glands, i.e. xerostomia, which occurs at relatively low doses. This complication leads to mouth dryness which is the most common problem for head and neck cancer survivors. There are dif...
متن کاملCochlea sparing effects of intensity modulated radiation therapy in head and neck cancers patients: a long-term follow-up study.
BACKGROUND Radiation to the inner ear may lead to (irreversible) sensorineural hearing loss. The purpose of this study was to evaluate the long-term effect of radiotherapy on hearing in patients treated with Intensity Modulated Radiation Therapy (IMRT), sparing the inner ear from high radiation dose as much as possible. METHODS Between 2003 and 2006, 101 patients with head and neck cancer wer...
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ژورنال
عنوان ژورنال: Radiation Oncology
سال: 2015
ISSN: 1748-717X
DOI: 10.1186/s13014-015-0501-x