Normal Spastin Gene Dosage Is Specifically Required for Axon Regeneration
نویسندگان
چکیده
منابع مشابه
Drosophila Spastin Regulates Synaptic Microtubule Networks and Is Required for Normal Motor Function
The most common form of human autosomal dominant hereditary spastic paraplegia (AD-HSP) is caused by mutations in the SPG4 (spastin) gene, which encodes an AAA ATPase closely related in sequence to the microtubule-severing protein Katanin. Patients with AD-HSP exhibit degeneration of the distal regions of the longest axons in the spinal cord. Loss-of-function mutations in the Drosophila spastin...
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Mutations in >50 genes, including spastin and atlastin, lead to hereditary spastic paraplegia (HSP). We previously demonstrated that reduction of spastin leads to a deficit in axon regeneration in a Drosophila model. Axon regeneration was similarly impaired in neurons when HSP proteins atlastin, seipin, and spichthyin were reduced. Impaired regeneration was dependent on genetic background and w...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2012
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2012.09.032