Normal physiology and HIV pathophysiology of human T-cell dynamics

Normal physiology and HIV pathophysiology of human T-cell dynamics.

Physiology and pathophysiology of the mesangial cell

The intercapillary area of the kidney glomerulus was first described and named «mesangium» by Zimmermann in 1933 1. The advent of electron microscopy enabled Marinozzi in Italy 2 and Latta in the U.S. 3 to conclusively demonstrate that a separate cell type exists in the kidney glomerulus, in addition to epithelial and endothelial cells lining around the basement membrane. The functions of these...

Frequency of Human T-Cell Lymphotropic Virus (HTLV) Type 1 and 2 Infection in HIV Infected Patients

Background and Objectives: Human T-cell lymphotropic viruses (HTLV) type 1 and 2 are retroviruses that share the same routes of transmission as human immunodeficiency virus (HIV). As a consequence of epidemiologic similarities, HIV and HTLV-1/2 co-infection is frequent. Due to the limited data, this study assessed the seroprevalence of HTLV-1/2 infections in HIV infected patients in Tehran, Ira...

Leptin in human physiology and pathophysiology.

Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted hormone with pleiotropic effects in the physiology and pathophysiology of energy homeostasis, endocrinology, and metabolism. Studies in vitro and in animal models highlight the potential for leptin to regulate a number of physiological functions. Available evidence from human studies indicates that leptin has a...

Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology.

Identification of Lgr5 as the intestinal stem cell marker as well as the growth factors necessary to replicate adult intestinal stem cell division has led to the establishment of the methods to generate "indefinite" ex vivo primary intestinal epithelial cultures, termed "mini-intestines." Primary cultures developed from isolated intestinal crypts or stem cells (termed enteroids/colonoids) and f...