منابع مشابه
Normal and Neoplastic Stem Cells
A stem cell is broadly defined as a cell that retains the capacity to self-renew, a feature that confers the ability to continuously make identical daughter cells or additional cells that will differentiate into downstream progeny. This highly regulated genetic program to retain "stemness" is under active investigation. Research in our laboratory has explored similarities and differences in emb...
متن کاملneoplastic bone marrow niche: hematopoietic and mesenchymal stem cells
the neoplastic niche comprises complex interactions between multiple cell types and molecules requiring cell-cell signaling as well as local secretion. these niches are important for both the maintenance of cancer stem cells and the induction of neoplastic cells survival and proliferation. each niche contains a population of tumor stem cells supported by a closely associated vascular bed compri...
متن کاملDeath in normal and neoplastic cells.
It is well known that cell loss occurs from growing neoplasms in vivo. This is particularly prominent in slowly growing tumours, including many human examples (Steel, 1967), and in some cases the rate of cell loss may be as much as 80% of the rate of cell production (Terz, Curutchet, and Lawrence, 1971). Whilst metastasis and desquamation may account for some of the observed cell loss much of i...
متن کاملNeoplastic and Normal Cells in Culture
Despite intensive efforts for several decades, our understanding of tumor cell biology is at the stage where we are still trying to formulate the basic questions involved. We have found that neoplastic cells have subtle alterations in such fundamental processes as cell proliferation, differentiation, and morphogenesis, areas only barely understood in normal cells. Nevertheless, a great deal has...
متن کاملNormal and neoplastic nonstem cells can spontaneously convert to a stem-like state.
Current models of stem cell biology assume that normal and neoplastic stem cells reside at the apices of hierarchies and differentiate into nonstem progeny in a unidirectional manner. Here we identify a subpopulation of basal-like human mammary epithelial cells that departs from that assumption, spontaneously dedifferentiating into stem-like cells. Moreover, oncogenic transformation enhances th...
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ژورنال
عنوان ژورنال: Cold Spring Harbor Symposia on Quantitative Biology
سال: 2016
ISSN: 0091-7451,1943-4456
DOI: 10.1101/sqb.2016.81.030965