Norborn-2-en-7-ones as physiologically-triggered carbon monoxide-releasing prodrugs
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Norborn-2-en-7-ones as physiologically-triggered carbon monoxide-releasing prodrugs.
A prodrug strategy for the release of the gasotransmitter CO at physiological pH, based upon 3a-bromo-norborn-2-en-7-one Diels-Alder cycloadducts of 2-bromomaleimides and 2,5-dimethyl-3,4-diphenylcyclopentadienone has been developed. Examples possessing protonated amine and diamine groups showed good water solubility and thermal stability. Half-lives for CO-release in TRIS-sucrose buffer at pH ...
متن کاملNorborn-2-en-7-ones as physiologically-triggered carbon monoxide-releasing prodrugs† †Electronic supplementary information (ESI) available: Experimental details for the synthesis of compounds, supporting figures and schemes, and NMR spectra. See DOI: 10.1039/c7sc01647f Click here for additional data file.
A prodrug strategy for the release of the gasotransmitter CO at physiological pH, based upon 3a-bromonorborn-2-en-7-one Diels–Alder cycloadducts of 2-bromomaleimides and 2,5-dimethyl-3,4diphenylcyclopentadienone has been developed. Examples possessing protonated amine and diamine groups showed good water solubility and thermal stability. Half-lives for CO-release in TRIS-sucrose buffer at pH 7....
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ژورنال
عنوان ژورنال: Chemical Science
سال: 2017
ISSN: 2041-6520,2041-6539
DOI: 10.1039/c7sc01647f