Nontransfusional Iron Overload in Thalassemia: Association With Hereditary Hemochromatosis
نویسندگان
چکیده
منابع مشابه
Nontransfusional iron overload in thalassemia. Association with hereditary hemochromatosis.
genes. Hemochromatosis is inherited as an autosomal recessive trait and The Cys282Tyr mutation was detected in only 1 of the 81 individis manifested by excessive absorption of dietary iron in homozygotes uals with thalassemia intermedia. The proband presented in 1975 at leading to complications of iron overload and premature death. In the age of 42 years with joint pains. Hepatomegaly was noted...
متن کاملCoincidental nontransfusional iron overload and thalassemia minor: association with HLA-linked hemochromatosis.
A pedigree was studied in which five individuals with beta-thalassemia minor were found to have nontransfusional hemochromatosis. Three were children under the age of 10 and two were young male adults, ages 28 and 33. A 5-yr-old child without evidence of thalassemia also had hemochromatosis. Since hemochromatosis is transmitted as an HLA-linked autosomal recessive disorder, HLA haplotypes serve...
متن کاملIron Overload and Thalassemia Minor: Association With HLA-Linked Hemochromatosis
A pedigree was studied in which five individuals with fl-thalassemia minor were found to have nontransfusional hemochromatosis. Three were children under the age of 10 and two were young male adults. ages 28 and 33. A 5-yr-old child without evidence of thalassemia also had hemochromatosis. Since hemochromatosis is transmitted as an HIA-linked autosomal recessive disorder. HLA haplotypes serve a...
متن کاملIron-Overload–Related Disease in HFE Hereditary Hemochromatosis
Katrina J. Allen, M.D., Ph.D., Lyle C. Gurrin, Ph.D., Clare C. Constantine, Ph.D., Nicholas J. Osborne, Ph.D., Martin B. Delatycki, M.D., Ph.D., Amanda J. Nicoll, M.D., Ph.D., Christine E. McLaren, Ph.D., Melanie Bahlo, Ph.D., Amy E. Nisselle, B.Sc., Chris D. Vulpe, M.D., Ph.D., Gregory J. Anderson, Ph.D., Melissa C. Southey, Ph.D., Graham G. Giles, Ph.D., Dallas R. English, Ph.D., John L. Hopp...
متن کاملIron-overload-related disease in HFE hereditary hemochromatosis.
BACKGROUND Most persons who are homozygous for C282Y, the HFE allele most commonly asssociated with hereditary hemochromatosis, have elevated levels of serum ferritin and transferrin saturation. Diseases related to iron overload develop in some C282Y homozygotes, but the extent of the risk is controversial. METHODS We assessed HFE mutations in 31,192 persons of northern European descent betwe...
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ژورنال
عنوان ژورنال: Blood
سال: 1997
ISSN: 1528-0020,0006-4971
DOI: 10.1182/blood.v90.8.3234