Nonreciprocality of a micromachine driven by a catalytic chemical reaction

We propose a model that describes cyclic state transitions of micromachine driven by catalytic chemical reaction. consider mechanochemical coupling variables representing the degree reaction and internal micromachine. The total free energy consists tilted periodic potential energy. assume variable obeys deterministic stepwise dynamics characterized two typical timescales, i.e., mean first passage time transition path time. To estimate functionality micromachine, we focus on quantity called ``nonreciprocality'' further discuss its dependence properties For example, show nonreciprocality is proportional to square explicit calculation timescales within decoupling approximation reveals inversely barrier