منابع مشابه
Cationization of Protein Antigens
Cationization of BSA generates a molecule that mounts antibody responses of increased magnitude and duration and induces T cell proliferation at concentrations 500 times less than native BSA (nBSA). To explain the alteration in immunogenic properties of this Ag, the uptake of nBSA and cationized BSA (cBSA) by splenic APC has been investigated. T cell proliferation assays were conducted with nBS...
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Although ant ibodies against nuclear antigens are considered the hal lmark of systemic lupus e ry thematosus (SLE) 1, antibodies against cytoplasmic consti tuents have also been identified (1, 2). Despite their recogni t ion more than 25 years ago, the prevalence, antigenic specificities, and disease associations of antir ibosomal antibodies (ARA) are all controversial (3-10) . Since these prob...
متن کاملComposite Vertical Structure of Vertical Velocity in Nonprecipitating Cumulus Clouds
Vertical transects of Doppler vertical velocity data, obtained from an airborne profiling millimeter-wave cloud radar, are composited for a large number of cumulus clouds (Cu) at various stages of their life cycle, to examine typical circulations patterns. The Cu clouds range in depth between ;500 and 6000 m and are generally nonprecipitating. They were sampled on board the University of Wyomin...
متن کاملTermination of Acquired Immunological Tolerance to Protein Antigens following Immunization with Altered Protein Antigens
Acquired tolerance to BSA in rabbits was terminated following the injection of certain preparations of altered BSA. Injections of Freund's adjuvant containing BSA complexed to anti-BSA, heat-denatured BSA, acetyl-BSA, picryl-BSA, or arsanil-BSA failed to terminate the tolerant state. Except in an occasional tolerant rabbit, injections of these preparations failed to cause the production of prec...
متن کاملReview Interactions of protein antigens with antibodies
There are now several crystal structures of antibody Fab fragments complexed to their protein antigens. These include Fab complexes with lysozyme, two Fab complexes with influenza virus neuraminidase, and three Fab complexes with their anti-idiotype Fabs. The pattern of binding that emerges is similar to that found with other proteinprotein interactions, with good shape complementarity between ...
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ژورنال
عنوان ژورنال: Nature
سال: 1941
ISSN: 0028-0836,1476-4687
DOI: 10.1038/148593a0