Nonparametric Procedure for Identifying the Minimum Effective Dose with Ordinal Response Data
نویسندگان
چکیده
منابع مشابه
Nonparametric identification of the minimum effective dose.
We consider identifying the minimum effective dose (MED) in a dose-response study, where the MED is defined to be the lowest dose level producing an effect over that of the zero-dose control. Proposed herein is a nonparametric procedure based on the Mann-Whitney statistic incorporated with the step-down closed testing scheme. A numerical example demonstrates the feasibility of the proposed nonp...
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In this paper, we consider identifying the minimum effective dose (MED) in a doseresponse study with randomly right-censored lifetime data, where the MED is the lowest dose level with a median lifetime larger than that of the zero-dose control by a certain threshold value. The MED is identified based on the stepwise confidence sets for the ratios of median lifetimes of each non-zero dose group ...
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About 25 years ago, McCullagh proposed a method for modeling univariate ordinal responses. After publishing this paper, other statisticians gradually extended his method, such that we are now able to use more complicated but efficient methods to analyze correlated multivariate ordinal data, and model the relationship between these responses and host of covariates. In this paper, we aim to...
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One primary purpose in a dose–response study for drug development is to identify the minimum effective dose (MED), which is the lowest dose level producing an effect over that of the zero-dose control. Proposed herein is a nonparametric step-down closed testing procedure for identifying the MED in a randomized block design with one or more observations per cell. The associated p-value of the id...
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ژورنال
عنوان ژورنال: Communications for Statistical Applications and Methods
سال: 2004
ISSN: 2287-7843
DOI: 10.5351/ckss.2004.11.3.597