Nonlinear machine learning pattern recognition and bacteria-metabolite multilayer network analysis of perturbed gastric microbiome

نویسندگان

چکیده

Abstract The stomach is inhabited by diverse microbial communities, co-existing in a dynamic balance. Long-term use of drugs such as proton pump inhibitors (PPIs), or bacterial infection Helicobacter pylori , cause significant alterations. Yet, studies revealing how the commensal bacteria re-organize, due to these perturbations gastric environment, are early phase and rely principally on linear techniques for multivariate analysis. Here we disclose importance complementing dimensionality reduction with nonlinear ones unveil hidden patterns that remain unseen embedding. Then, prove advantages complete pattern analysis differential network analysis, reveal mechanisms re-organizations which emerge from induced medical treatment (PPIs) an infectious state ( H. ). Finally, show build bacteria-metabolite multilayer networks can deepen our understanding metabolite pathways significantly associated perturbed communities.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Machine Learning Pattern Recognition

Introduction These lecture notes were written to provide you with a handy reference to the material that was presented in the Machine Learning: Pattern Recognition course. It is not meant to replace the book of the course [Bishop, 2007], rather, it is meant to illustrate topics that may seem a bit dry or emphasise subjects that are deemed important to this class. It will often repeat what was s...

متن کامل

Pattern Recognition and Machine Learning

his book provides an introduction to the eld of pattern recognition and machine earning. It gives an overview of several asic and advanced topics in machine earning theory. The book is definitely aluable to scientists and engineers who re involved in developing machine learnng tools applied to signal and image proessing applications. This book is also uitable for courses on machine learning nd ...

متن کامل

Pattern Recognition and Machine Learning

In this note, we describe the sequential minimal optimization (SMO) algorithm to solve the soft margin support vector machine (SVM) binary classification problem, which is to be implemented as part of the miniproject. In order to understand our arguments here, the reader is advised to study the SVM chapter of the course notes, in particular the “Solving the Support Vector Machine” section (the ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Nature Communications

سال: 2021

ISSN: ['2041-1723']

DOI: https://doi.org/10.1038/s41467-021-22135-x