Nonlinear machine learning pattern recognition and bacteria-metabolite multilayer network analysis of perturbed gastric microbiome
نویسندگان
چکیده
Abstract The stomach is inhabited by diverse microbial communities, co-existing in a dynamic balance. Long-term use of drugs such as proton pump inhibitors (PPIs), or bacterial infection Helicobacter pylori , cause significant alterations. Yet, studies revealing how the commensal bacteria re-organize, due to these perturbations gastric environment, are early phase and rely principally on linear techniques for multivariate analysis. Here we disclose importance complementing dimensionality reduction with nonlinear ones unveil hidden patterns that remain unseen embedding. Then, prove advantages complete pattern analysis differential network analysis, reveal mechanisms re-organizations which emerge from induced medical treatment (PPIs) an infectious state ( H. ). Finally, show build bacteria-metabolite multilayer networks can deepen our understanding metabolite pathways significantly associated perturbed communities.
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2021
ISSN: ['2041-1723']
DOI: https://doi.org/10.1038/s41467-021-22135-x