Noninvasive Protein Structural Flexibility Mapping by Bimodal Dynamic Force Microscopy
نویسندگان
چکیده
منابع مشابه
Noninvasive protein structural flexibility mapping by bimodal dynamic force microscopy.
Mapping of the protein structural flexibility with sub-2-nm spatial resolution in liquid is achieved by combining bimodal excitation and frequency modulation force microscopy. The excitation of two cantilever eigenmodes in dynamic force microscopy enables the separation between topography and flexibility mapping. We have measured variations of the elastic modulus in a single antibody pentamer f...
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ژورنال
عنوان ژورنال: Physical Review Letters
سال: 2011
ISSN: 0031-9007,1079-7114
DOI: 10.1103/physrevlett.106.198101