Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound

Noninvasive Treatment of Breast Cancer Using High-Intensity Focused Ultrasound

Breast conserving surgery is a standard procedure for breast cancer since 1970. Now noninvasive therapy with few complications is preferred. High-intensity focused ultrasound (HIFU) has been developed to ablate solid tumor or cancer noninvasively. Its clinical outcome on breast cancer in China and Europe as well as the induced vascular destruction and immune response are summarized. In summary,...

MR-guided high-intensity focused ultrasound for noninvasive cancer treatment

Magnetic resonance (MR)-high-intensity focused ultrasound (HIFU) is an innovative, noninvasive tumour ablation technique. MR imaging and focused ultrasound are combined allowing real-time anatomic guidance and temperature mapping during treatment. Recently, the volumetric ablation approach has been introduced in order to reduce treatment length and provide more homogeneous tumour ablation. Afte...

High-intensity focused ultrasound for noninvasive functional neurosurgery.

Transcranial magnetic resonance (MR)-guided high-intensity focused ultrasound (tcMRgHIFU) implies a novel, noninvasive treatment strategy for various brain diseases. Nine patients with chronic neuropathic pain were treated with selective medial thalamotomies. Precisely located thermal ablations of 4mm in diameter were produced at peak temperatures of 51 degrees C to 60 degrees C under continuou...

A Prototype Stimulator System for Noninvasive Low Intensity Focused Ultrasound Delivery

A prototype Low Intensity Focused Ultrasound (LIFU) stimulator system was developed to evaluate non-invasive neuromodulation in a large animal model. We conducted a feasibility study on a Göttingen minipig, demonstrating reversible, targeted transcranial neuromodulation. The hypothalamus of the minipig was repeatedly stimulated with LIFU which evoked temporally correlated increases in both hear...

High-Intensity Focused Ultrasound –