Noninvasive Fetal Trisomy (NIFTY) test: an advanced noninvasive prenatal diagnosis methodology for fetal autosomal and sex chromosomal aneuploidies
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چکیده
منابع مشابه
Author's response to reviews Title: Noninvasive Fetal Trisomy (NIFTY) Test An Advanced Noninvasive Prenatal Diagnosis Methodology for Fetal Autosomal and Heterosomal Aneuploidies Authors:
Fuman Jiang ([email protected]) Jinghui Ren ([email protected]) Fang Chen ([email protected]) Yuqiu Zhou ([email protected]) Jiansheng Xie ([email protected]) Shan Dan ([email protected]) Yue Su ([email protected]) Jianhong Xie ([email protected]) Baomin Yin ([email protected]) Wen Su ([email protected]) Huakun Zhang ([email protected]) Wei Wang ([email protected]) ...
متن کاملClinical utility of noninvasive fetal trisomy (NIFTY) test – early experience
OBJECTIVE To report the initial experience of noninvasive prenatal diagnosis of fetal Down syndrome (The NIFTY test) in a clinical setting. METHODS The NIFTY test was offered as a screening test for fetal Down syndrome to pregnant women with a singleton pregnancy at 12 weeks of gestation or beyond. A satisfaction questionnaire was sent to the first 400 patients. RESULTS During a 6-month per...
متن کامل[Non-invasive fetal trisomy (NIFTY) test in prenatal diagnosis].
NIFTY (Non-invasive Fetal Trisomy Test) is a non-invasive prenatal test which is used for diagnosing fetal trisomy. The test is based on the analysis of cell free fetal DNA (cffDNA) present in the plasma and serum of a pregnant woman. NIFTY allows to detect fetal trisomy of chromosomes 13, 18, 21, X and Y and also X monosomy. Abnormal NIFTY results still need to be verified using other diagnost...
متن کاملMeDIP Real-Time qPCR has the Potential for Noninvasive Prenatal Screening of Fetal Trisomy 21
This study aimed to verify the reliability of the 7 tissue differentially methylated regions used in the methylated DNA immunoprecipitation (MeDIP) real-time quantitative polymerase chain reaction (real-time qPCR) based approach of fetal DNA in maternal blood to diagnosis of fetal trisomy 21. Forty pregnant women with high risk pregnancy who were referred after first or second trimester screeni...
متن کاملNoninvasive prenatal diagnosis of common fetal chromosomal aneuploidies by maternal plasma DNA sequencing.
OBJECTIVE To develop a new bioinformatic method in the noninvasive prenatal identification of common fetal aneuploidies using massively parallel sequencing on maternal plasma. METHODS Massively parallel sequencing was performed on plasma DNA samples from 108 pregnant women (median gestation: 12(+5) week) immediately before chorionic villus sampling (CVS) or amniocentesis. Data were analysed u...
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ژورنال
عنوان ژورنال: BMC Medical Genomics
سال: 2012
ISSN: 1755-8794
DOI: 10.1186/1755-8794-5-57