Nondystrophic myotonia: Challenges and future directions
نویسندگان
چکیده
منابع مشابه
Mexiletine for symptoms and signs of myotonia in nondystrophic myotonia: a randomized controlled trial.
CONTEXT Nondystrophic myotonias (NDMs) are rare diseases caused by mutations in skeletal muscle ion channels. Patients experience delayed muscle relaxation causing functionally limiting stiffness and pain. Mexiletine-induced sodium channel blockade reduced myotonia in small studies; however, as is common in rare diseases, larger studies of safety and efficacy have not previously been considered...
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ژورنال
عنوان ژورنال: Experimental Neurology
سال: 2014
ISSN: 0014-4886
DOI: 10.1016/j.expneurol.2013.12.005