Non-Procrustean pathways for complex generic drugs development

The concept of: Generic drugs and patented drugs vs. brand name drugs and non-proprietary (generic) name drugs

Time and again the importance of generic prescribing has been emphasized, primarily to reduce the cost of drugs (Mukherjee, 2013). There are two concepts to be understood here, one is generic vs. patented drugs and the other is a drug’s “brand name” vs. “non-proprietary name” or “generic name.” Although, our article primarily describes the Indian scenario, it can be extrapolated to other countr...

Development of 177Lu-phytate Complex for Radiosynovectomy

Objective(s): In this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation. Materials and Methods: Lu-177 of 2.6-3 GBq/mg specific activity was obtained by irradiation of natural Lu2O3 sample with thermal neutron flux of 4 × 1013 n.cm-2.s-1. The product was converted into chloride form which was further used for labeling of 177Lu-phytate complex and che...

Shape Manifolds, Procrustean Metrics, and Complex Projective Spaces

The shape-space l.m whose points a represent the shapes of not totally degenerate /c-ads in IR m is introduced as a quotient space carrying the quotient metric. When m = 1, we find that Y\ = S~; when m ^ 3, the shape-space contains singularities. This paper deals mainly with the case m = 2, when the shape-space I* c a n be identified with a version of CP*~. Of special importance are the shape-m...

Bioequivalence of generic drugs.

Generic drugs are bioequivalent to the original brand; this is a prerequisite for marketing approval. It is theoretically possible that one generic drug may overestimate the pharmacokinetic (PK) parameters of the original and another generic may underestimate these PK parameters; in consequence, these 2 generics may not be bioequivalent between themselves. The result could be loss of efficacy o...

Clarification regarding generic substitution for psychotropic drugs.