Non-Myeloablative Stem Cell Transplantation
نویسندگان
چکیده
منابع مشابه
Non-myeloablative allogeneic peripheral stem cell transplantation for multiple myeloma.
OBJECTIVE To present an institution's 2-year experience of non-myeloablative allogeneic stem cell transplantation among Chinese patients. DESIGN Retrospective study. SETTING Bone marrow transplantation unit at a university hospital, Hong Kong. PATIENTS Ten patients with multiple myeloma who received non-myeloablative allogeneic stem cell transplantation between March 2000 and October 2002...
متن کاملPrevalence of chimerism after non-myeloablative hematopoietic stem cell transplantation.
CONTEXT AND OBJECTIVE Non-myeloablative hematopoietic stem cell transplantation (NMA-HSCT) is performed in onco-hematological patients who cannot tolerate ablative conditioning because of older age or comorbidities. This approach does not completely eliminate host cells and initially results in mixed chimerism. Long-term persistence of mixed chimerism results in graft rejection and relapse. Inv...
متن کاملNon-myeloablative transplantation.
The concept of utilizing enhanced immunosuppression rather than myeloablative cytotoxic conditioning has allowed the engraftment of allogeneic stem cells from related and unrelated donors with lower early transplant-related mortality (TRM) and morbidity. This approach shifts tumor eradication to the graft-vs-host immune response directed against minor histocompatibility antigens expressed on tu...
متن کاملAllogeneic haemopoietic stem cell transplantation using non-myeloablative conditioning--a local experience.
Allogeneic haemopoietic stem cell transplantation was initially considered as a means of delivering supralethal doses of chemotherapy with or without total body irradiation for the treatment of malignancy. However, it has become clear that this mode of therapy does not eradicate the malignancy in many patients and its benefit is largely due to the immune mediated graft versus malignancy effect....
متن کاملSafe and effective use of outpatient non-myeloablative allogeneic stem cell transplantation for myeloma
Multiple myeloma (MM) remains incurable despite widespread deployment of novel agents and high-dose melphalan/autologous stem cell transplantation (ASCT) earlier in the disease course. Recently, non-myeloablative (NMA) allogeneic stem cell transplantation (allo SCT) has been introduced in an attempt to exploit the well-documented graft-versus-myeloma effect (GVM), while at the same time reducin...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2001
ISSN: 0268-3369,1476-5365
DOI: 10.1038/sj.bmt.1702837