Non-MHC antigens and their relative resistance to immunosuppression after corneal transplantation

Non-HLA antigens and HLA-DR matching in corneal transplantation.

Immunosuppression after Liver Transplantation

Sensitization to human lymphocyte antigens by corneal transplantation.

Although corneal transplantation is performed on patients with densely vascularized corneas, the likelihood of immunologic rejection is greater than in the nonvascularized cornea. In other organ transplantation systems, immune rejection has been correlated with the degree of antigenic disparity of the major histocompatibility antigens (HL-A) between the donor and the recipient. In this study, w...

Intrathymic Presentation of Circulating Non - Mhc Antigens

The generation of the T cell repertoire, the site and mechanism of T cell subset bifurcation, and the selective constraints exerted on the developing repertoire to ensure self-tolerance are still poorly understood. The assignment of these events to either the pre-, intra-, or postthymic stages of T cell maturation has been aided by the recent development of mAb to the antigen-specific T cell re...

Towards Steroid-Free Immunosuppression after Liver Transplantation

The deleterious long-term side effects and metabolic complications of corticosteroids have inspired initial clinical investigation of corticosteroid withdrawal and avoidance protocols in liver transplantation. The original studies in the 1990s focused on the safety of steroid withdrawal in patients without hepato-cellular carcinoma (HCC). 1,2 Subsequent clinical trials suggested noninferiority ...