Non-mercaptalbumin is significantly associated with the coronary plaque burden and the severity of coronary artery disease

Abstract Human non-mercaptalbumin (HNA), oxidized form of serum albumin, has been reported as a useful marker in oxidative stress-related diseases; however, few reports have examined the association between HNA and severity coronary artery disease (CAD). The present study evaluated whether fraction is correlated with stenosis 140 patients considered to high risk CAD or who were suspected having acute syndrome. was defined by number stenotic vessels score system (the Gensini score). measurements performed using our newly established high-performance liquid chromatography methodology. results had shown that significantly increased three-vessel disease, compared those without single-vessel ( p = 0.025), positively (ρ 0.421, < 0.001). A multivariate analysis showed an independent significant factor associated 1.246, 0.012). logistic regression strong predictor multivessel (odds ratio, 1.12; 95% confidence interval, 1.020–1.229; 0.017). These findings indicate measurement could be clinically practical for predicting stenosis.