Non-invasive imaging using reporter genes altering cellular water permeability
نویسندگان
چکیده
منابع مشابه
Non-invasive imaging using reporter genes altering cellular water permeability
Non-invasive imaging of gene expression in live, optically opaque animals is important for multiple applications, including monitoring of genetic circuits and tracking of cell-based therapeutics. Magnetic resonance imaging (MRI) could enable such monitoring with high spatiotemporal resolution. However, existing MRI reporter genes based on metalloproteins or chemical exchange probes are limited ...
متن کاملNoninvasive molecular imaging using reporter genes.
Noninvasive reporter gene imaging is a component of molecular imaging. Reporter imaging can provide noninvasive assessments of endogenous biologic processes in living subjects and can be performed using different imaging modalities. This review will focus on radionuclide-based reporter gene imaging as developed and applied in preclinical and clinical studies. Examples of different reporter syst...
متن کاملMRI Reporter Genes for Noninvasive Molecular Imaging.
Magnetic resonance imaging (MRI) is one of the most important imaging technologies used in clinical diagnosis. Reporter genes for MRI can be applied to accurately track the delivery of cell in cell therapy, evaluate the therapy effect of gene delivery, and monitor tissue/cell-specific microenvironments. Commonly used reporter genes for MRI usually include genes encoding the enzyme (e.g., tyrosi...
متن کاملNon-invasive Melanoma Diagnosis using Multispectral Imaging
The early analysis of pigmented skin lesions is important for clinicians in order to recognize malignant melanoma. However, it is difficult to differentiate it from benign skin lesions due to their similarity based on their appearance. Since melanoma has a tendency to grow inside the skin and the depth of penetration of light into the skin is wavelength dependent, a multispectral imaging acquis...
متن کاملBacterial Thymidine Kinase as a Non-Invasive Imaging Reporter for Mycobacterium tuberculosis in Live Animals
BACKGROUND Bacteria can be selectively imaged in experimentally-infected animals using exogenously administered 1-(2'deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-[(125)I]-iodouracil ([(125)I]-FIAU), a nucleoside analog substrate for bacterial thymidine kinase (TK). Our goal was to use this reporter and develop non-invasive methods to detect and localize Mycobacterium tuberculosis. METHODOLOGY/P...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Communications
سال: 2016
ISSN: 2041-1723
DOI: 10.1038/ncomms13891