Non-imprinted Igf2r expression decreases growth and rescues the Tme mutation in mice

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Non-imprinted Igf2r expression decreases growth and rescues the Tme mutation in mice.

In the mouse the insulin-like growth factor receptor type 2 gene (Igf2r) is imprinted and maternally expressed. Igf2r encodes a trans-membrane receptor that transports mannose-6-phosphate tagged proteins and insulin-like growth factor 2 to lysosomes. During development the receptor reduces the amount of insulin-like growth factors and thereby decreases embryonic growth. The dosage of the gene i...

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Unregulated expression of the imprinted genes H19 and Igf2r in mouse uniparental fetuses.

The present study shows that the H19 and Igf2r genes, which are imprinted and expressed solely from maternal alleles, are expressed in an unregulatable manner in mouse uniparental, androgenetic, and parthenogenetic fetuses at day 9.5 of gestation. In the androgenetic fetuses, the H19 and Igf2r genes were respectively expressed at 12 and 40% of the levels in biparental fetuses. In addition, the ...

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Expression of the p56(Lck) Y505F mutation in CD45-deficient mice rescues thymocyte development.

Mice deficient in the transmembrane protein tyrosine phosphatase CD45 exhibit a block in thymocyte development. To determine whether the block in thymocyte development was due to the inability to dephosphorylate the inhibitory phosphorylation site (Y505) in p56(lck) (Lck), we generated CD45-deficient mice that express transgenes for the Lck Y505F mutation and the DO11.10 T-cell antigen receptor...

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Unregulated Expression of the Imprinted Genes H19 and Igf2r in Mouse Uniparental Fetuses Running Title: Imprinted Genes in Mouse Uniparetnal Fetuses

1 Department of Animal Science, Tokyo University of Agriculture, 1737, Funako, Atsugi, Kanagawa 243-0034, Japan, 2 Gene Research Center, Gunma University, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan, 3 Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, 1,111, Yata, Mishima, Shizuoka 411-8540, Japan, and 4 Department of BioScience, Tokyo Univ...

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ژورنال

عنوان ژورنال: Development

سال: 2001

ISSN: 1477-9129,0950-1991

DOI: 10.1242/dev.128.10.1881