Non-High Density Lipoprotein Cholesterol: A Modern Benchmark for Assessing Lipid Metabolism Disorders

Aim . To perform a population analysis of Non-High Density Lipoprotein Cholesterol level (non-HDL-c) in Russian and to evaluate its association with cardiovascular events. Material Methods The material consisted results obtained from 11 regions the ESSE-RF1 Study 4 ESSE-RF2 Study. protocols were identical. studies performed 2012-2014 2017, respectively. Endpoints assessed 19041 people aged 35-64 years. median follow-up was 6.5 years ESSE RF (1) 3.8 RF(2). Analysis for three lipid variables: total cholesterol (TC), low-density lipoprotein (LDL-C), non-HDLC two samples: general sample same without individuals coronary heart disease (CHD), myocardial infarction (MI) and/or stroke history not taking statins (the "without diseases [CVD]". nonlinear associations using generalized additive Cox model. combined endpoint represented by death nonfatal MI stroke. Traditional laboratory FRs, socio-demographic parameters analyzed. significance all tested hypotheses set be 0.05. Results prevalence elevated non-HDL-C (>3.7 mmol/l) found 74.6%. No gender differences found: there 74.6% men 74.5% women. Both mean values increased age women, slightly decreased after 55 old. Almost analyzed RFs significantly associated these samples. In both samples CH LDL-C all-cause mortality correction RFs. On contrary, CVD end pints. It has been shown that risk points increases uniformly increase levels non HDL cholesterol, no found. Conclusion population-based first time confirmed contribute determining events medium term. can assumed new scales (SCORE2 SCORE OP) proposed European Society Cardiology Preventive Cardiology, which include non-HDL C instead TC, will allow adequate assessment 10-year Russians. However, continued monitoring endpoints order obtain stable is required.