Non genetic risk factors of long-QT syndrome

Non genetic risk factors of Long-QT Syndrome

The purpose of the present study is to provide guidelines regarding risk factors that may worsen the LongQT Syndrome (LQTS), based on available literature. This review evaluates the current knowledge on these risk factors of acquired LQTS, with an emphasis on non genetic risk factors, including environmental factors. PubMed was searched for literature in English from 1999 to 2011 on the molecul...

Genetic testing for long QT syndrome.

Genetic Modifiers for the Long-QT Syndrome

The long-QT syndrome (LQTS), probably the best-known genetic disorder causing life-threatening arrhythmias, has become a useful paradigm to study sudden cardiac death in the young. An intriguing feature of LQTS is its incomplete penetrance and variable expressivity which are commonly observed even among members of the same family, all carriers of the same mutation. There is a consensus that thi...

Long QT syndrome - a genetic cardiac channelopathy.

INTRODUCTION Long QT-syndrome (LQTS) is a genetic cardiac channelopathy characterised by a prolonged QT interval on a surface electrocardiogram (ECG), syncope, T-wave abnormalities, ventricular tachycardia of the torsades de pointes (TdPVT) type (Fig. 1) and an increased risk of sudden death [1]. LQTS has variable clinical presentation and is genetically characterised by incomplete penetrance, ...

Long QT Syndrome- A Genetic Insight

Ethnicity Genetics Long QT syndrome LQTS Molecular pathogenesis Sudden cardiac death