Non-Equilibrium Gating in Cardiac Na + Channels
نویسندگان
چکیده
منابع مشابه
Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia.
BACKGROUND Many long-QT syndrome (LQTS) mutations in the cardiac Na+ channel result in a gain of function due to a fraction of channels that fail to inactivate (burst), leading to sustained current (Isus) during depolarization. However, some Na+ channel mutations that are causally linked to cardiac arrhythmia do not result in an obvious gain of function as measured using standard patch-clamp te...
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ژورنال
عنوان ژورنال: Circulation
سال: 2003
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.0000069273.51375.bd