Non-enzymatic glycosylation in human diabetic lens crystallins
نویسندگان
چکیده
منابع مشابه
Diabetic cataract formation: potential role of glycosylation of lens crystallins.
A high glucose concentration in vivo or an increased glucose of glucose 6-phosphate concentration in vitro has been found to lead to the glycosylation of epsilon-amino groups of lysine residues in bovine and rat lens crystallins. In vitro, this glycosylation imparts an increased susceptibility of the crystallins to sulfhydryl oxidation. Disulfide crosslinks result in the formation of high molec...
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We have recently demonstrated that singlet oxygen-mediated photooxidation can cause an increase in blue fluorescence and covalent cross-linking in bovine lens crystallins in vitro. Because these changes closely parallel modifications known to occur in human crystallins during aging and cataractogenesis, it was suggested that singlet oxygen may play an important role in these processes in vivo. ...
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Non-enzymatic glycosylation reaction, which proceeded at an accelerated rate in diabetes, directly caused sharp diminution of total haemoglobin due to glycosylated proteins including haemoglobin digested by macrophages. The diminution contributed to hypoxia of tissue that repressed the enzymatic activities in the respiratory chain as well as in the tri-carboxylic acid cycle (TCA) and Embden-Mey...
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The ontogeny of the lens crystallin antigens throughout development of three marine cephalopod embryos, Loligo vulgaris, Sepia officinalis and Octopus vulgaris has been investigated using the indirect immuno-cytochemical staining against respective homologous anti-total lens protein antiserum. The cellular mechanism of lens development appears to be the same in all species investigated and so d...
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D mellitus (DM) is associated with a greatly increased risk of secondary complications, such as cutaneous manifestations, myocardial infarction, nephropathy, retinopathy, and polyneuropathy. The non-enzymatic glycation of proteins followed by the formation of advanced glycation end products (AGEs) plays an important role in the pathology of diabetic complications.1 Occasionally endocrinological...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1986
ISSN: 0012-186X,1432-0428
DOI: 10.1007/bf00454880