منابع مشابه
Non cholinergic toxicity of Sarin.
Sarin attacks occurred both in Matsumoto and in Tokyo in 1994-1995; more than 15 people died because of such attacks. The acute toxic effect of Sarin nerve gas (organophosphorus: OP) produces miotic pupils as well as reduced cholinesterase (ChE) activities, which are nicotinic and muscarinic signs. A cholinergic sign may not be the sole mechanism of OP toxicity. Suzuki et al (1) described the f...
متن کاملSarin experiences in Japan: acute toxicity and long-term effects.
Two terrorist attacks with the nerve agent Sarin affected citizens in Matsumoto and Tokyo, Japan in 1994 and 1995, killing 19 and injuring more the 6000. Sarin, a very potent organophosphate nerve agent, inhibits acetylcholinesterase (AchE) activity within the central, peripheral, and autonomic nervous systems. Acute and long-term Sarin effects upon humans were well documented in these two even...
متن کاملSensorimotor deficit and cholinergic changes following coexposure with pyridostigmine bromide and sarin in rats.
A myriad of neurological symptoms including muscle and joint pain, ataxia, chronic fatigue, headache, and difficulty in concentration have been reported by Persian Gulf War (PGW) veterans. A large number of these veterans were prophylactically treated with pyridostigmine bromide (PB) and possibly exposed to sarin. In the present study we investigated the effects of PB and sarin, alone and in co...
متن کاملNon-cholinergic functions of acetylcholinesterase.
24 Schalk, I., Ehret-Sabatier, I,., Houet, F., Goeldner, M. and Hirth, C. (1994) Eur. J. Hiochem. 219, 155-159 2.5 Harel, M., Sussman, J. I,., Krejci, E.> Hon, S., Chanal. P., Massoulie, J. and Silman. I. (1992) Proc. Natl. Acad. Sci. LJSA. 89, 108271083 1 26 Eichler, J.. Anselmet, A,, Sussman, J. I,.. Massoulie, J. and Silman, 1. (1994) Mol. Pharmacol. 45, 335-340 27 Kadic, Z.. I’ickering, N.,...
متن کاملNeuroprotective mechanisms activated in non-seizing rats exposed to sarin
Exposure to organophosphate (OP) nerve agents, such as sarin, may lead to uncontrolled seizures and irreversible brain injury and neuropathology. In rat studies, a median lethal dose of sarin leads to approximately half of the animals developing seizures. Whereas previous studies analyzed transcriptomic effects associated with seizing sarin-exposed rats, our study focused on the cohort of sarin...
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ژورنال
عنوان ژورنال: Internal Medicine
سال: 1997
ISSN: 0918-2918,1349-7235
DOI: 10.2169/internalmedicine.36.447