Non-Calcium-Containing Phosphate Binders: Comparing Efficacy, Safety, and Other Clinical Effects
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چکیده
منابع مشابه
Non-calcium-containing phosphate binders: comparing efficacy, safety, and other clinical effects.
Phosphate-binder therapy for hyperphosphataemia is key to the treatment of patients with chronic kidney disease (CKD)-mineral and bone disorder (MBD). Calcium-free phosphate binders are increasingly favoured since calcium-based agents potentially cause harmful calcium overload and vascular calcification that confound the benefits of reducing serum phosphorus. Several calcium-free phosphate bind...
متن کاملThe effects of non-calcium-based phosphate binders versus calcium-based phosphate binders on cardiovascular calcification and bone remodeling among dialysis patients: a meta-analysis of randomized trials.
BACKGROUND Vascular calcification significantly increases the rates of cardiovascular mortality in hemodialysis (HD) patients. Abnormalities in mineral metabolism may play a role in the pathogenesis of arterial calcification. Whether patients treated with non-calcium-based phosphate binders had reduced aortic vascular calcification compared to those treated with calcium-based phosphate binders ...
متن کاملUnintentional non-adherence to phosphate binders
To cite: Patel P, Antoniou S, Popat R. Eur J Hosp Pharm 2015;22: 18–22. ABSTRACT Objectives The aim of this study was to determine patient specific perceptual and practical barriers to adherence to phosphate binders. The second stage aimed to determine the effectiveness of an adherence enhancing strategy trialled by patients. Methods A prospective, cross sectional study of patients attending a ...
متن کاملComparative effectiveness of calcium-containing phosphate binders in incident U.S. dialysis patients.
BACKGROUND AND OBJECTIVES Few studies have assessed the association between phosphate binder use and hard outcomes in dialysis patients. Furthermore, the comparative effectiveness of calcium carbonate and acetate is untested. We studied the association between use versus nonuse of calcium-containing phosphate binders (CCPBs) and mortality from any cause. We also tested whether mortality differe...
متن کاملEffects of phosphate binders in moderate CKD.
Some propose using phosphate binders in the CKD population given the association between higher levels of phosphorus and mortality, but their safety and efficacy in this population are not well understood. Here, we aimed to determine the effects of phosphate binders on parameters of mineral metabolism and vascular calcification among patients with moderate to advanced CKD. We randomly assigned ...
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ژورنال
عنوان ژورنال: Nephron Clinical Practice
سال: 2012
ISSN: 1660-2110
DOI: 10.1159/000337087