منابع مشابه
Interaction Between Mitochondria and Caspases: Apoptotic and Non-Apoptotic Roles
Mitochondria, play an important role in a variety of processes including energy production, apoptosis, autophagy and inflammation. Caspases, are proteases that play an essential role in mediating apoptotic process of programmed cell death. An association between mitochondria and caspases is very well defined during apoptosis. Besides apoptosis, emerging data is strongly suggesting a direct asso...
متن کاملActivation of Pro-apoptotic Caspases in Non-apoptotic Cells During Odontogenesis and Related Osteogenesis
Caspases are well known proteases in the context of inflammation and apoptosis. Recently, novel roles of pro-apoptotic caspases have been reported, including findings related to the development of hard tissues. To further investigate these emerging functions of pro-apoptotic caspases, the in vivo localisation of key pro-apoptotic caspases (-3,-6,-7,-8, and -9) was assessed, concentrating on the...
متن کاملAre metacaspases caspases?
The identification of caspases as major regulators of apoptotic cell death in animals initiated a quest for homologous peptidases in other kingdoms. With the discovery of metacaspases in plants, fungi, and protozoa, this search had apparently reached its goal. However, there is compelling evidence that metacaspases lack caspase activity and that they are not responsible for the caspaselike acti...
متن کاملMultiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells.
The activity of ICE-like proteases or caspases is essential for apoptosis. Multiple caspases participate in apoptosis in mammalian cells but how many caspases are involved and what is their relative contribution to cell death is poorly understood. To identify caspases activated in apoptotic cells, we developed an approach to simultaneously detect multiple active caspases. Using tumor cells as a...
متن کاملNon-apoptotic function of caspases in a cellular model of hydrogen peroxide-associated colitis
Oxidative stress, caused by reactive oxygen species (ROS), is a major contributor to inflammatory bowel disease (IBD)-associated neoplasia. We mimicked ROS exposure of the epithelium in IBD using non-tumour human colonic epithelial cells (HCEC) and hydrogen peroxide (H2 O2 ). A population of HCEC survived H2 O2 -induced oxidative stress via JNK-dependent cell cycle arrests. Caspases, p21(WAF1) ...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2011
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn3026