منابع مشابه
Biosynthesis of penicillins; new crystalline biosynthetic penicillins.
Paper III (1) in this series describes several tests which were found to be useful in determining whether a given compound is utilized by the mold in penicillin formation. To provide proof of the incorporation of various acyl groups into the penicillin molecule and to be able to determine the chemical characteristics and biological properties of the various penicillins, isolation and crystalliz...
متن کاملTissue Distribution of Penicillins.
WHILE it is of obvious importance to determine the antibacterial activity of a penicillin in the blood it is perhaps of greater importance to know what concentrations are present in the extravascular fluids. In view of the current interest in protein binding and its influence on activity it is also of importance to determine in what way binding influences distribution throughout the body. Usual...
متن کاملToxicity of the Penicillins.
THE absence of direct toxicity is one of the most remarkable properties of the penicillin molecule; that is to say, the penicillin molecule as we know it and as we should use it. If you try hard enough, you can make it toxic by altering it or abusing it, as I shall try to show later. With this reservation, one can say that penicillin G and the main therapeutic derivatives of 6-aminopenicillanic...
متن کاملPenicillins and cephalosporins.
Resemblances and differences between the penicillins (I) and cephalosporins (II) are considered from a chemical and biochemical point of view.
متن کاملAntibacterial activity of the penicillins.
Penicillin, the first antibiotic of clinical importance to be discovered, is in many ways the best. Against most pathogenic species of Gram-positive bacteria and Gramnegative cocci a concentration of 0.02 ptg./ml.t or less inhibits growth and a concentration not much higher is actively bactericidal. Moreover, apart from hypersensitivity reactions, penicillin is probably the least toxic of the a...
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ژورنال
عنوان ژورنال: Infection
سال: 1975
ISSN: 0300-8126,1439-0973
DOI: 10.1007/bf01641059