Noggin Is Required for Correct Guidance of Dorsal Root Ganglion Axons
نویسندگان
چکیده
منابع مشابه
Neuregulin-mediated ErbB3 signaling is required for formation of zebrafish dorsal root ganglion neurons.
Dorsal root ganglia (DRGs) arise from trunk neural crest cells that emerge from the dorsal neuroepithelium and coalesce into segmental streams that migrate ventrally along the developing somites. Proper formation of DRGs involves not only normal trunk neural crest migration, but also the ability of DRG progenitors to pause at a particular target location where they can receive DRG-promoting sig...
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As axons form connections in the developing brain, they often change course before they reach their final target. An outstanding question concerning changes in axon guidance is whether autonomous gene expression directs axons to their targets. If autonomous gene expression is required during axon guidance, then at least some aspects of guidance may be irreversible. Once commissural axons cross ...
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The axons of the spinal intersegmental interneurons are projected longitudinally along various funiculi arrayed along the dorsal-ventral axis of the spinal cord. The roof plate and the floor plate have a profound role in patterning their initial axonal trajectory. However, other positional cues may guide the final architecture of interneuron tracks in the spinal cord. To gain more insight into ...
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Elongation of the efferent fibers of dorsal root ganglion (DRG) neurons toward their peripheral targets occurs during development. Attractive or permissive systems may be involved in this elongation. However, the molecular mechanisms that control it are largely unknown. Here we show that class 5 semaphorin Sema5A had attractive/permissive effects on DRG axons. In mouse embryos, Sema5A was expre...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2002
ISSN: 0012-1606
DOI: 10.1006/dbio.2002.0829