NOD1/CARD4(G796A) and NOD2/CARD15(R702W, G908R and L1007fsinC) polymorphisms associated with Crohn's disease in Iraqi patients
نویسندگان
چکیده
Inflammatory bowel disease (IBD) applies to two main forms of chronic relapsing inflammatory intestinal disorders: Crohn's (CD), Ulcerative colitis (UC). CD requires an irregular immune reaction that induces intense inflammation. The cause is not yet fully known; previous research, however, indicated inflammation the intestines elevated or continues due inappropriate responses associations between genetic factors, microbiota, and environmental factors contributing production IBD. This study aimed investigate predisposing genes, single nucleotide Polymorphisms (SNPs) NOD1/CARD4 NOD2/CARD15) with in Iraqi patients. common NOD1 (G796A) SNP NOD2 SNPs R702W, G908R L1007fsinC for were selected. Thirty citizens a recognized diagnosis twenty apparently healthy controls included from November 2019 December 2020; polymorphisms have been screened by polymerase chain reaction/restriction analysis length polymorphism (PCR/RFLP). results current investigation studied patients controls, allelic genotypic data show highly significant association G796A disease, GA percentage was 56.67% as compared genotype (0.00%). Furthermore, G allele more than A 0.72 vs. 0.28. Also, frequency distribution (R702W, G908R, L1007fs) patients, revealed connection susceptibility. proportion GC 30% while 0% control group, 0.85 vs 0.15 respectively, which allele. There no changes frequencies R702W L1007fs present concluded predisposition And also be effective. While other L1007fsinsC NOD2, showed Keywords: NOD1/CARD4, NOD2/CARD15, polymorphisms.
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ژورنال
عنوان ژورنال: Bionatura (Ibarra - Impresa)
سال: 2022
ISSN: ['1390-9347', '1390-9355']
DOI: https://doi.org/10.21931/rb/2022.07.03.38