منابع مشابه
Sensitivity of BK Channels
Functional large-conductance Ca 2 and voltage-activated K (BK) channels can be assembled from four subunits (Slo1) alone, or together with four auxiliary 1 subunits to greatly increase the apparent Ca 2 sensitivity of the channel. We examined the structural features involved in this modulation with two types of experiments. In the first, the tail domain of the subunit, which includes the RCK2 (...
متن کاملSingle-channel kinetics of BK (Slo1) channels
Single-channel kinetics has proven a powerful tool to reveal information about the gating mechanisms that control the opening and closing of ion channels. This introductory review focuses on the gating of large conductance Ca(2+)- and voltage-activated K(+) (BK or Slo1) channels at the single-channel level. It starts with single-channel current records and progresses to presentation and analysi...
متن کاملRINm5f cells express inactivating BK channels whereas HIT cells express noninactivating BK channels.
Large-conductance Ca2+- and voltage-activated BK-type K+ channels are expressed abundantly in normal rat pancreatic islet cells and in the clonal rat insulinoma tumor (RINm5f) and hamster insulinoma tumor (HIT) beta cell lines. Previous work has suggested that the Ca2+ sensitivity of BK channels in RIN cells is substantially less than that in HIT cells, perhaps contributing to differences betwe...
متن کاملGating Mechanism of BK (Slo1) Channels
Large conductance calciumand voltage-activated K channels (Slo1), also referred to as “BK” or “maxi K” channels because of their high single channel conductance (250–300 pS in symmetrical 150 mM KCl), are widely distributed in many different tissues (Kaczorowski et al., 1996). A signature feature of BK channels, in addition to their high K selectivity and conductance, is that they are activated...
متن کاملMartentoxin: a unique ligand of BK channels.
The large-conductance calcium-activated potassium (BK) channels distributed in both excitable and non-excitable cells are key participants in a variety of physiological functions. By employing numerous high-affinity natural toxins originated from scorpion venoms the pharmacological and structural characteristics of these channels tend to be approached. A 37-residue short-chain peptide, named as...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2019
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2018.11.595