No significant long-term complications from inadvertent exposure to gonadotropin-releasing hormone agonist during early pregnancy in mothers and offspring: a retrospective analysis

Abstract Background Administration of gonadotropin-releasing hormone agonist (GnRH-a) in the luteal phase is commonly used for pituitary suppression during vitro fertilisation (IVF). There an ineluctable risk inadvertent exposure spontaneous pregnancy to GnRH-a. However, little known about complications and repregnancy outcomes affected women neurodevelopmental GnRH-a-exposed children. Methods Retrospective analysis was determine obstetric after natural conception 114 who naturally conceived while receiving GnRH-a their early over past 17 years. The children were evaluated neonatal characteristics long-term outcomes. compared those relevant age-matched control groups. Results Sixty-five had 66 live births. health incidence maternal similar Thirty-one children, aged 2–8 years, available investigation neurodevelopment. Except one case autism spectrum disorder, full-scale intelligence quotient score within normal range that group. Most mothers with successful pregnancies one-third abortions subsequently able conceive again. IVF recommended have experienced ectopic pregnancies. Conclusions Accidental might be safe. Reproductive treatment suggestions should made consideration previously pregnancy.