منابع مشابه
NO more muscle fatigue.
NOS is a key enzyme in the production of NO, a molecule that directly regulates vasorelaxation and blood supply. Diverse forms of muscle disease have been clinically associated with unusual fatigue after exercise. The localization of neuronal NOS (nNOS) at the plasma membrane of muscle has recently been shown to prevent muscle fatigue after exercise. In this issue of the JCI, Lai et al. show th...
متن کاملNo rest for fatigue researchers.
F atigue is the most important side effect of cancer and cancer treatment, according to a recent study of patients and professionals in major cancer centers across the United States. Led by David Cella, Ph.D., at Evanston Northwestern Healthcare and Northwestern University's cancer center in Chicago, the study confirms not only that cancer-related fatigue is common but also that it affects pati...
متن کاملNeurobiology of muscle fatigue.
Muscle fatigue encompasses a class of acute effects that impair motor performance. The mechanisms that can produce fatigue involve all elements of the motor system, from a failure of the formulation of the descending drive provided by suprasegmental centers to a reduction in the activity of the contractile proteins. We propose four themes that provide a basis for the systematic evaluation of th...
متن کاملMuscle fatigue measured with evoked muscle vibrations.
Skeletal muscle vibrates laterally during voluntary and evoked muscle contractions. We hypothesized that the vibration amplitude from evoked muscle twitches is directly related to evoked twitch force from fatiguing muscle. To test the hypothesis, vibrations produced by evoked muscle twitches were recorded during short (5-second) rest periods as the muscle was intermittently exercised with volun...
متن کاملCentrosomes: Central no more?
It has recently been found that the zygotic development of a morphologically normal fly can occur without properly functioning mitotic centrosomes. Does this mean that centrosomes are not required for cell division in animals at all?
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2009
ISSN: 0021-9738
DOI: 10.1172/jci38618