No exit: Targeting the budding process to inhibit filovirus replication
نویسندگان
چکیده
منابع مشابه
Electron Tomography Reveals the Steps in Filovirus Budding
The filoviruses, Marburg and Ebola, are non-segmented negative-strand RNA viruses causing severe hemorrhagic fever with high mortality rates in humans and nonhuman primates. The sequence of events that leads to release of filovirus particles from cells is poorly understood. Two contrasting mechanisms have been proposed, one proceeding via a "submarine-like" budding with the helical nucleocapsid...
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Inactivation of mitotic cyclin-dependent kinases (Cdks) is required for cells to exit mitosis [1] [2]. In the budding yeast Saccharomyces cerevisiae, Cdk inactivation is triggered by the phosphatase Cdc14, which is activated by a complex network of regulatory proteins that includes the protein kinase Cdc15 [3] [4] [5] [6]. Here we show that the ability of Cdc15 to promote mitotic exit is inhibi...
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ژورنال
عنوان ژورنال: Antiviral Research
سال: 2009
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2008.12.003