No clinically significant pharmacokinetic interactions between dolutegravir and daclatasvir in healthy adult subjects
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منابع مشابه
No clinically significant pharmacokinetic interactions between dolutegravir and daclatasvir in healthy adult subjects
BACKGROUND Daclatasvir (DCV) is an NS5A replication complex inhibitor recently approved for chronic hepatitis C virus treatment. METHODS To assess drug interactions between the HIV integrase strand transfer inhibitor dolutegravir (DTG) and DCV, subjects were randomized into 1 of 2 sequences in an open-label, 3-period, crossover study. Subjects received either DTG 50 mg once daily or DCV 60 mg...
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BACKGROUND AND OBJECTIVE Almorexant is the first representative of the new class of orexin receptor antagonists, which could become a new treatment option for insomnia. The present study investigated the potential interaction between almorexant and warfarin. METHODS In this open-label, two-way crossover, drug-drug interaction study, healthy male subjects received, in a randomized fashion, alm...
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ژورنال
عنوان ژورنال: BMC Infectious Diseases
سال: 2016
ISSN: 1471-2334
DOI: 10.1186/s12879-016-1629-5