NMR spectroscopic characterization of β-cyclodextrin inclusion complex with vanillin

NMR spectroscopic characterization of β- cyclodextrin inclusion complex with vanillin

Solid State Characterization of Domperidone: Hydroxypropyl-β-Cyclodextrin Inclusion Complex

The purpose of the present study was to prepare inclusion complex of domperidone with hydroxylpropyl-β-cyclodextrin in order improved the solubility and hence to increase dissolution of domperidone. An effect of concentration of hydroxylpropyl-β-cyclodextrin on the aqueous solubility of domperidone was determined by phase-solubility method. The aqueous solubility of domperidone increased as a f...

Β-cyclodextrin Inclusion Complex of Curcumin

Formation of inclusion complex of curcumin with β-cyclodextrin ( β-CD) has been characterized by absorption and fluorescence spectroscopy. From temperature-dependent fluorescence measurements, the thermodynamic parameters ∆H and ∆S, for the complexation were estimated. Kinetics of binding was studied by stopped flow technique, from which the binding constants for inclusion complex was estimated...

Investigation of Inclusion Complex of Patchouli Alcohol with β-Cyclodextrin

The objective of this study was to improve the stability and water-solubility of patchouli alcohol by complexing with β-cyclodextrin (β-CD). The interactions between patchouli alcohol and β-CD were characterized by differential scanning calorimetry (DSC), Fourier transformation-infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), and Scanning electron microscope (SEM), respectively. ...

Molecular recognition of flunarizine dihydrochloride and β-cyclodextrin inclusion complex by NMR and computational approaches

BACKGROUND Flunarizine dihydrochloride (FLN) is used in the prophylactic treatment of migraine, vertigo, occlusive peripheral vascular disease and epilepsy. Cyclodextrins (CDs) are chiral, truncated cone shaped macrocycles known for their inner hydrophobic and outer hydrophilic site. They form complexes with hydrophobic drug molecules and enhance the solubility and bioavailability of such compo...