NMR based quantitation of cycloartane triterpenes in black cohosh extracts

Black Cohosh

New 3,4-seco-cycloartane triterpenes from Gardenia sootepensis.

Two new 3,4-seco-cycloartane triterpenes, named sootepins H (1) and I (2), were isolated from the ethyl acetate extract of the leaves and twigs of Gardenia sootepensis. Their structures were elucidated on the basis of 1D- and 2D-nuclear magnetic resonance (NMR) analysis, as well as high-resolution mass spectrometry (HR-MS), infrared (IR), and ultra violet (UV).

Black Cohosh - American Family Physician

Uses and Efficacy Currently, the primary use of black cohosh extract is for alleviation of menopausal symptoms. The American College of Obstetrics and Gynecology guidelines on the use of botanicals for the management of menopausal symptoms support this use for up to six months, especially in treating the symptoms of sleep and mood disturbance, and hot flushes. [Evidence level C, consensus/exper...

Black Cohosh Considerations of Safety and Benefit

Joseph M. Betz, PhD Linda Anderson, PhD Mark I. Avigan, MD Joanne Barnes, PhD Norman R. Farnsworth, PhD Barbro Gerdén, MD Leigh Henderson, MS Edward J. Kennelly, PhD Uwe Koetter, PhD Stephanie Lessard, MS Tieraona Low Dog, MD, PhD Michelle McLaughlin, BS Belal Naser, MD Ruediger G. W. Osmers, MD, PhD Linda S. Pellicore, PhD John R. Senior, PhD Richard B. van Breemen, PhD Wolfgang Wuttke, MD Joh...

Cytotoxic cycloartane triterpenes of the traditional Chinese medicine "shengma" (Cimicifuga dahurica).

Twelve new 9,19-cycloartane triterpenes (1-12), together with fourteen known compounds (13-26), were isolated from the roots of Cimicifuga dahurica. Their structures were determined by application of spectroscopic analyses and chemical methods. Biological evaluation of the compounds against human HL-60, SMMC-7721, A549, MCF-7, and SW-480 cell lines indicated that cimigenol-type glycosides (1-3,...