NMDA antagonists as Parkinson’s disease therapy: disseminating the evidence
نویسندگان
چکیده
منابع مشابه
Manual Therapy Choices: A General Approach to Parkinsons Disease
In treating dysfunction, it is normal for most therapists to use a variety of modalities and methods including myofascial release, muscle-energy techniques, positional-release techniques and many more. The assumption must be that different tools achieve different effects, and the ones we choose reflect our perception as to the needs of the individual and/or of the tissues involved. Sledgehammer...
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Much evidence points to the involvement of N-methyl-D-aspartate (NMDA) receptors in the development and maintainance of neuropathic pain. In neuropathic pain, there is generally involved a presumed opioid-insensitive component, which apparently can be blocked by NMDA receptor antagonists. However, in order to obtain complete analgesia, a combination of an NMDA receptor antagonist and an opioid ...
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OBJECTIVE: To investigate the effects of N-methyl-D-aspartate (NMDA) receptor antagonists on restraint-induced release of prolactin (PRL) in male Wistar rats of different ages. DESIGN: Rats were implanted with a brain ventricular for icv injection, and with a jugular vein cannula for iv injection. Competitive NMDA receptor antagonist AP-5 and noncompetitive NMDA receptor blocker MK-801 was inje...
متن کاملNeuroprotection, excitotoxicity and NMDA antagonists.
PURPOSE To analyze the main aspects of neuroprotection and excitotoxicity. DISCUSSION This is a significant theory on the pathophysiology of cerebral ischemia; it is based on the release of excitatory aminoacid (EAA), mainly glutamate. The sequence starts with a decrease of the blood flow and ends in neuronal death. The main stages of this reaction are herein presented and discussed. An in de...
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There is increasing evidence for the involvement of glutamate-mediated neurotoxicity in the pathogenesis of Alzheimer's disease (AD). We suggest that glutamate receptors of the N-methyl-D-aspartate (NMDA) type are overactivated in a tonic rather than a phasic manner in this disorder. This continuous mild activation may lead to neuronal damage and impairment of synaptic plasticity (learning). It...
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ژورنال
عنوان ژورنال: Neurodegenerative Disease Management
سال: 2014
ISSN: 1758-2024,1758-2032
DOI: 10.2217/nmt.13.77