NLRP3 inflammasome as a novel target for cystic fibrosis treatment

Abstract Background Inflammasomes are intracellular multiprotein complexes that sense danger signals from damaged cells and pathogens assemble to mediate caspase-1 activation, which results in the proteolytic cleavage of pro-IL-1β IL-18 into bioactive forms. The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is a critical component innate immune system mediates activation secretion proinflammatory cytokines IL-1β/IL-18 response disturbances cellular homeostasis caused by microbial infections damage. Main body abstract NLRP3 associated with various inflammatory disorders, including Alzheimer’s disease, diabetes, atherosclerosis. In recent years, has also been implicated inflammation cystic fibrosis. differentiation pro-IL-1β–IL-1β, an active cytokine, mediated neutrophil expression inflammasome. Furthermore, it maintains cytokine storm lungs during pathogenesis CF. Short conclusion This review highlights metabolic reprogramming characterized Warburg effect, NLRP3-mediated fibrosis, its inhibition as potential therapeutic strategy.