NKX2-5 Mutations in an Inbred Consanguineous Population: Genetic and Phenotypic Diversity
نویسندگان
چکیده
منابع مشابه
NKX2-5 Mutations in an Inbred Consanguineous Population: Genetic and Phenotypic Diversity
NKX2-5 mutations are associated with different forms of congenital heart disease. Despite the knowledge gained from molecular and animal studies, genotype-phenotype correlations in humans are limited by the lack of large cohorts and the incomplete assessment of family members. We hypothesized that studying the role of NKX2-5 in inbred populations with homogeneous genetic backgrounds and high co...
متن کاملphylogeography and genetic diversity of the lesser mouse- eared bat (myotis blythii) in iran
in current study, 63 samples of bat populations collected from differ regions were used for evaluating the geographic variations. twenty cranial and dental characters for traditional morphometric and landmarks method on the ventral, dorsal skull and mandible for geometry morphometric studies were used. statistical analyses of traditional morphometric and geometry morphometric data indicated low...
Genetic Diversity and Relationships of Agronomic Characters in Wheat Recombinant Inbred Lines
Objective: Wheat is the most important crop in Iran. Self sufficiency in wheat production is one of the economic and food safety policies in the country. In spite of the efforts which have been made in this area, the mean of wheat yield in Iran is less than its world average. Methods: In order to identifying of the high yielding wheat lines with optimal characteristics and to determine the trai...
متن کاملThe Ambiguous Role of NKX2-5 Mutations in Thyroid Dysgenesis
NKX2-5 is a homeodomain-containing transcription factor implied in both heart and thyroid development. Numerous mutations in NKX2-5 have been reported in individuals with congenital heart disease (CHD), but recently a select few have been associated with thyroid dysgenesis, among which the p.A119S variation. We sequenced NKX2-5 in 303 sporadic CHD patients and 38 families with at least two indi...
متن کاملGenetic Diversity and Relationships of Agronomic Characters in Wheat Recombinant Inbred Lines
Objective: Wheat is the most important crop in Iran. Self sufficiency in wheat production is one of the economic and food safety policies in the country. In spite of the efforts which have been made in this area, the mean of wheat yield in Iran is less than its world average. Methods: In order to identifying of the high yielding wheat lines with optimal characteristics and to determine the trai...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2015
ISSN: 2045-2322
DOI: 10.1038/srep08848