منابع مشابه
NK, NKT and Invariant-NKT Cells in Tumor Draining Lymph Nodes of Patients with Breast Cancer
Background: NK (natural killer) and NKT (natural killer T) cells, as components of innate immune system, play a crucial role in tumor progression and dissemination. Objective: To investigate the percentages of NK cells, NKT cells, iNKT (invariant natural killer T) cells, total T lymphocytes as well as activated T lymphocytes, in tumor draining lymph nodes (TDLN...
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نوتروپنی در صورتی که منجر به شوک عفونی گردد، میتواند باعث مرگ بیمار شود مقابله با عفونت، شامل بررسی دقیق، مراقبت های پیشگیری کننده و مداخله به موقع می باشد. بیماران سرطانی بستری در بیمارستانها، اغلب در معرض خطر عفونت قرار دارند. بویژه اگر احتیاج به درمان شدید با روش های تشخیمی داشته باشند. هرگونه عفونت می تواند تهدیدی برای زندگی بیماران دارای نوتروپنی محسوب شود.
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The TIM (T cell immunoglobulin mucin) proteins have emerged as key regulators of allergic and autoimmune diseases due to their influence on T helper (Th)-1 and Th-2 responses. On page 955, Chen and colleagues show that one member of this family, TIM-2, multitasks as a receptor for H-ferritin, a component of the iron storage protein ferritin. Ferritin was not what the group expected to find when...
متن کاملTrouble-making NKT cells
The dark side of NKT cells is revealed in a new study showing that they contribute to autoimmune arthritis in mice. On page 41, Kim et al. find that arthritis is worse in joints that are invaded by NKT cells. NKT cells are innate immune cells that express both NK and T cell markers, and are protective in many other models of autoimmune disease. The authors tested NKT function in K/BxN mice—an e...
متن کاملNovel Approaches to Exploiting Invariant NKT Cells in Cancer Immunotherapy
iNKT cells are a subset of innate-like T cells that utilize an invariant TCR alpha chain complexed with a limited repertoire of TCR beta chains to recognize specific lipid antigens presented by CD1d molecules. Because iNKT cells have an invariant TCR, they can be easily identified and targeted in both humans and mice via standard reagents, making this a population of T cells that has been well ...
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ژورنال
عنوان ژورنال: Science
سال: 2010
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.330.6008.1156-d