منابع مشابه
Nitroglycerin tolerance in human vessels: evidence for impaired nitroglycerin bioconversion.
BACKGROUND The basis for progressive attenuation of the effects of organic nitrates during long-term therapy (nitrate tolerance) remains controversial; proposed mechanisms include impaired nitrate bioconversion resulting in decreased release of nitric oxide (NO) from nitrates and/or increased NO clearance through a reaction with incrementally generated superoxide (O(2)(-)). METHODS AND RESULT...
متن کاملEffects of Nitroglycerin
Twenty-three patients exhibiting coronary insufficiency on exercise have been studied at rest and at exercise prior to and following sublingual administration of nitroglycerin. The most consistent and marked effect of nitroglycerin was the reduction in pulmonary artery pressure, total pulmonary resistance, and right ventricular work at rest and during exercise. Our patients were grouped accordi...
متن کاملNitroglycerin and Nitrate Tolerance
Background. The present study was designed to investigate the intracellular production of cyclic GMP (cGMP) in platelets in response to nitroglycerin and to determine the potential clinical value of platelet cGMP as an indicator of the effects of nitroglycerin and nitrate tolerance. Methods and Results. Platelet cGMP levels and the diameters of the coronary arteries before and 2 minutes after i...
متن کاملEffects of Sublingual Nitroglycerin
I. Moss AJ, Rivers RJ Jr, Griffith LSC, Carmel JA, Millard EB Jr: Transvenous left atrial pacing for the control of recurrent ventricular fibrillation. N Engl J Med 278: 928, 1968 2. Moss AJ, Rivers RJ Jr, Cooper M: Long-term pervenous atrial pacing from the proximal portion of the coronary vein. JAMA 209: 543, 1969 3. Kramer DH, Moss AJ: Permanent pervenous atrial pacing from the coronary vein...
متن کاملThe nitroglycerin-flicker test.
The nitroglycerin-flicker test, as suggested and modified by Krasno and Ivy, has been used to test normal individuals and patients with a variety of cardiovascular diseases. The hypothesis that this test would serve as an index of the presence of vascular disease or spasm elsewhere in the body than the retina was explored. These studies have failed to justify the drawing of conclusions based on...
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ژورنال
عنوان ژورنال: Reactions Weekly
سال: 2021
ISSN: ['1179-2051', '0114-9954']
DOI: https://doi.org/10.1007/s40278-021-98490-x