Nitric oxide synthase gene polymorphisms and diabetic nephropathy
نویسندگان
چکیده
منابع مشابه
Association of endothelial nitric oxide synthase gene G894T polymorphism with type two diabetes and diabetic nephropathy
Background: Nitric oxide (NO) produced by endothelial NO synthase (eNOS) mediates a large range of processes, and abnormality in the production of NO has been implicated in diabetic complications including diabetic nephropathy (DN). G894T polymorphism in the eNOS gene has been shown to decreased activity the NO levels of plasma. The association between eNOS Glu298Asp gene polymorphism and DN ri...
متن کاملEndothelial nitric oxide synthase gene polymorphisms and renal survival.
To the Editor: Development of end stage renal disease (ESRD) and a blunted in vitro generation of nitric oxide (NO) have been recently associated with the 298Asp substitution in the endothelial NO synthase (eNOS) gene.1 Diabetic nephropathy was the culprit of ESRD in most patients (pts);1 however, the same association was recently reported in pts with ESRD due to polycystic kidney disease.2 Col...
متن کاملNitric oxide synthase gene polymorphisms and prostate cancer risk.
Nitric oxide (NO) induces cytotoxicity and angiogenesis, and may play a role in prostate carcinogenesis, potentially modulated by environmental exposures. We evaluated the association of prostate cancer with genetic polymorphisms in two genes related to intracellular NO: NOS2A [inducible nitric oxide synthase (NOS); -2892T>C, Ex16 + 14C>T (S608L), IVS16 + 88T>G and IVS20 + 524G>A] and NOS3 [end...
متن کاملNitric oxide system and diabetic nephropathy
About 30% of patients with type 2 diabetes mellitus develop clinically overt nephropathy. Hyperglycemia is necessary, but not sufficient, to cause the renal damage that leads to kidney failure. Diabetic nephropathy (DN) is a multifactorial disorder that results from interaction between environmental and genetic factors. In the present article we will review the role of the nitric oxide synthase...
متن کاملEndothelial nitric oxide synthase gene polymorphisms in giant cell arteritis.
OBJECTIVE To examine potential associations of the Glu/Asp(298) polymorphism in exon 7 and the 4a/b polymorphism in intron 4 of the endothelial nitric oxide synthase (eNOS) gene with susceptibility to and clinical expression of giant cell arteritis (GCA), particularly in patients with versus those without ischemic complications. METHODS Ninety-one consecutive patients with biopsy-proven GCA, ...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2003
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-003-1046-3