Nitric Oxide Modulation by Folic Acid Fortification
نویسندگان
چکیده
منابع مشابه
Folic acid fortification and congenital heart disease.
Background: Low plasma folate concentrations in pregnancy are associated with preterm birth. Here we show an association between preconceptional folate supplementation and the risk of spontaneous preterm birth. Methods and Findings: In a cohort of 34,480 low-risk singleton pregnancies enrolled in a study of aneuploidy risk, preconceptional folate supplementation was prospectively recorded in th...
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The impact of folate on health and disease, particularly pregnancy complications and congenital malformations, has been extensively studied. Mandatory folic acid fortification therefore has been implemented in multiple countries, resulting in a reduction in the occurrence of neural tube defects. However, emerging evidence suggests increased folate intake may also be associated with unexpected a...
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A year-long prospective study conducted in the obstetrical service of Jinnah Postgraduate Medical Centre (JPMC), Karachi for the year 2002, observed 9892 deliveries (312 still-born). Amongst these, there were 34 births with various NTDs of whom there were 16 live births. Anencephaly was the commonest of the neural abnormalities (19 cases with only 3 live births) followed by 11 myelomeningocoele...
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My last column addressed folic acid and its benefits for pregnant women and their offspring. Specifically, the column focused on: a) folate for women at childbearing age and folate’s role in preventing both neural tube defects and other fetal abnormalities and learning and behavior problems in the offspring, and b) the possible benefits of folic acid for cancer prevention. This article continue...
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Acid-sensing ion channels (ASICs) are a class of ion channels activated by extracellular protons and are believed to mediate the pain caused by tissue acidosis. Although ASICs have been widely studied, little is known about their regulation by inflammatory mediators. Here, we provide evidence that nitric oxide (NO) potentiates the activity of ASICs. Whole-cell patch-clamp recordings were perfor...
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ژورنال
عنوان ژورنال: Antioxidants
سال: 2020
ISSN: 2076-3921
DOI: 10.3390/antiox9050393