Nitric Oxide as an Inflammatory Mediator in Autoimmune MRL-Ipr/Ipr Mice
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چکیده
منابع مشابه
Nitric oxide as an inflammatory mediator in autoimmune MRL-lpr/lpr mice.
Nitric oxide (.NO) may exhibit proinflammatory features. .NO synthase type 2 (NOS2) is overexpressed and .NO overproduced in rodent models of induced inflammation. Blockage of .NO production by administration of NOS inhibitors prevents or reduces various types of induced inflammation in mice and rats. We have shown that autoimmune MRL-lpr/lpr mice overexpress NOS2 and overproduce .NO in an age-...
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Nitric oxide (NO) is an important mediator of the inflammatory response. MRL-lpr/lpr mice overexpress inducible nitric oxide synthase (NOS2) and overproduce NO in parallel with the development of an autoimmune syndrome with a variety of inflammatory manifestations. In previous studies, we showed that inhibiting NO production with the nonselective nitric oxide synthase (NOS) inhibitor NG-monomet...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1998
ISSN: 0091-6765
DOI: 10.2307/3433975